Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50>16µM). Replace Sox2 during reprogramming mouse embryonic fibroblasts transduced with Oct4, Klf4 and c-Myc1,2
Product Specification:
Formula: C17H13N5
MW: 287.3
Purity: ≥98%
Appearance: Yellowish solid
Solubility: 5mg/ml soluble in DMSO or methanol
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stable for 2 years after receipt when stored at -20°C
Stock solutions are stable for up to 6 months when stored at -20°C
1.Ichida JK, Blanchard J, Lam K, et al. A Small-Molecule Inhibitor of Tgf-² Signaling Replaces Sox2 in Reprogramming by Inducing Nanog. Cell stem cell. 2009;5:491-503.
Maherali N, Hochedlinger K. Tgf² Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc. Current biology : CB. 2009;19:1718-1723
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