PS48 is an allosteric small molecule activator of phosphoinositide-dependent protein kinase 1 (PDK1) that binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of the only allosteric compounds that targets a regulatory binding site on
a protein kinase catalytic domain that is not adjacent to or overlaps with the ATP binding site. PS48
has been shown to enhance reprogramming of neonatal human epidermal keratinocytes (NHEKs) 1
Product Specification
Formula: C17H15ClO2
Molecular Weight: 286.75
Purity: ≥98% by HPLC
CAS Number: 1180678-32-7
Solubility: DMSO
Zhu S, Li W, Zhou H, et al. Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds. Cell stem cell. 2010;7:651-655
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