Selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and > 250 μM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC50 = 600nM). Smooth muscle relaxant and orally active in vivo. Increases survival rate of human
embryonic stem (hES) cells undergoing cryopreservation
Product Specification
M.Wt: 320.26
Formula: C14H21N3O.2HCl
Solubility: Soluble to 100 mM in water
Purity: >98 %
Storage: Desiccate at RT
CAS No: [146986-50-7]
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