Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site.
Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.
Enhances the efficiency of induced pluripotent stem cell (iPS) generation 1
Product Specification
M.Wt: 334.33
Formula: C19H14N2O4
Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity: >99 %
Storage: Store at RT
CAS No: [48208-26-0]
Shi Y, Desponts C, Do JT, et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell. 2008;3:568-574
|