Tankyrase (TNKS) inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the beta-catenin-dependent colon carcinoma cell line DLD-1 1
Product Specification
M.Wt: 312.31
Formula: C14H11F3N2OS
Solubility: Soluble to 50 mM in DMSO
Purity: >99 %
Storage: Store at RT
CAS No: [284028-89-3]
Huang, S.A., Mishina, Y.M., Liu, S., et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461 614-619 (2009)
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