Selective MEK1 and MEK2 inhibitor. Inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). Inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. The combination of PD0325901 and CHIR99021 can maintain the self-renewal of mouse ES cells without LIF 1. The combination of PD0325901 and SB431542 can significantly enhance human fibroblast reprogramming (>100 fold) 2.
Product Specification
M.Wt: 482.19
Formula: C16H14F3IN2O4
Solubility: Soluble to 100 mM in DMSO
Purity: >99 %
Storage: Store at -20°C
CAS No: [391210-10-9]
1. Ying QL, Wray J, Nichols J, et al. The ground state of embryonic stem cell self-renewal. Nature. 2008;453:519-523.
Lin T, Ambasudhan R, Yuan X, et al. A chemical platform for improved induction of human iPSCs. Nat Meth. 2009;6:805-808